James Heller is the same prototype as Mercer. The plot of the game describes their opposition in more detail, but there are several details Alex Mercer, the protagonist of the previous game, has become our main enemy. Sergeant James Heller lost his wife and child in the first part of the game, who were infected with the virus. Events of the second part of the famous slasher - Prototype - from the third person take us into the same area of life as the first part - New York.
